Development of a dissolution test for lamotrigine in tablet form using an ultraviolet method

Authors

  • Magda Targa Martins Universidade Federal do Rio Grande do Sul; Faculdade de Farmácia; Departamento de Farmácia
  • Clésio Soldatelli Paim Universidade Federal do Rio Grande do Sul; Faculdade de Farmácia; Departamento de Farmácia
  • Martin Steppe Universidade Federal do Rio Grande do Sul; Faculdade de Farmácia; Departamento de Farmácia

DOI:

https://doi.org/10.1590/S1984-82502010000200003

Keywords:

Lamotrigine, Dissolution test^i1^svalidat, Medicines^i1^squality cont

Abstract

A dissolution test for tablets containing 100 mg of lamotrigine was developed and validated. The dissolution test was applied to compare the dissolution profile of Neural® with the reference product Lamictal®. The analysis procedure was carried out using a simple ultraviolet method at 267 nm. After the determination of solubility and sink conditions, the parameters selected were paddles at 50 rpm, 900 mL of 0.01 M hydrochloric acid, and 30 minutes duration (single point). This method was validated for specificity, linearity, accuracy, precision and robustness. Lamotrigine stability was also evaluated in dissolution medium.

Downloads

Downloads

Published

2010-06-01

Issue

Vol. 46 No. 2 (2010)

Section

Original Papers

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on-line journal has open and free access.

How to Cite

Development of a dissolution test for lamotrigine in tablet form using an ultraviolet method . (2010). Brazilian Journal of Pharmaceutical Sciences, 46(2), 179-186. https://doi.org/10.1590/S1984-82502010000200003