A quantitative study of the influence of coprocessing of binders on the mechanical properties of paracetamol tablets

Authors

  • Abayomi Tolulope Ogunjimi Obafemi Awolowo University; Faculty of Pharmacy; Department of Pharmaceutics
  • Gbenga Alebiowu Obafemi Awolowo University; Faculty of Pharmacy; Department of Pharmaceutics

DOI:

https://doi.org/10.1590/S1984-82502010000200006

Keywords:

Coprocessing, Neem gum, Microcrystalline cellulose, Binder, Tensile strength, Brittle fracture index, Paracetamol

Abstract

A 2³ factorial experimental design has been used to quantitatively study individual and interaction effects of the nature of binder (N), concentration of binder (C) and the applied pressure (P) on two mechanical properties, namely, tensile strength (TS) and brittle fracture index (BFI), of paracetamol tablets. The factorial design was also used to study the quantitative effects of coprocessing of binders on the mechanical properties. The results obtained from this study suggest that the nature (i.e. plastic/elastic) and ratio of binders coprocessed together alter the influence of C and P on TS and BFI.

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Published

2010-06-01

Issue

Vol. 46 No. 2 (2010)

Section

Original Papers

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on-line journal has open and free access.

How to Cite

A quantitative study of the influence of coprocessing of binders on the mechanical properties of paracetamol tablets . (2010). Brazilian Journal of Pharmaceutical Sciences, 46(2), 205-212. https://doi.org/10.1590/S1984-82502010000200006