Validation of a spectrophotometric method to determine ciprofibrate content in tablets

Authors

  • Guilherme Nobre Lima do Nascimento Federal University of Goiás; Biochemistry and Neurosciences Laboratory
  • Daniel Lerner da Rosa Federal University of Goiás; Biochemistry and Neurosciences Laboratory
  • Hisao Nishijo University of Toyama; School of Medicine and Pharmaceutical Sciences
  • Tales Alexandre Aversi-Ferreira University of Toyama; School of Medicine and Pharmaceutical Sciences

DOI:

https://doi.org/10.1590/S1984-82502011000100004

Keywords:

Ciprofibrate^i1^sanaly, Spectrophotometric method^i1^smedicines analy, Medicines^i1^squality cont

Abstract

Ciprofibrate is a drug indicated in cases of hypertriglyceridemia and mixed hyperlipidemia, but no monographs are available in official compendia for the analysis of this substance in tablets. The objective of this work was to develop and validate a spectrophotometric method for routine analysis of ciprofibrate in tablets. In this study, commercial and standard ciprofibrate were used, as well as placebo in absolute ethanol, analyzed by UV spectrophotometer. All tests followed the rules of Resolution RE-899, 2003. The results showed that the developed and validated method offers low cost, easy implementation, precision and accuracy, and may be included in the routine of quality control laboratories.

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Published

2011-03-01

Issue

Vol. 47 No. 1 (2011)

Section

Articles

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on line journal has open and free access.

How to Cite

Validation of a spectrophotometric method to determine ciprofibrate content in tablets . (2011). Brazilian Journal of Pharmaceutical Sciences, 47(1), 23-29. https://doi.org/10.1590/S1984-82502011000100004