Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriers

Authors

  • Amanda Velinna Fernandes Manipal Academy of Higher Education, Manipal College of Pharmaceutical Sciences, Department of Pharmaceutics
  • Chinna Raja Pydi Manipal Academy of Higher Education, Manipal College of Pharmaceutical Sciences, Department of Pharmaceutics
  • Ruchi Verma Manipal Academy of Higher Education, Manipal College of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry https://orcid.org/0000-0002-1279-7243
  • Jobin Jose NITTE Deemed to be University, NGSM Institute of Pharmaceutical Sciences, Department of Pharmaceutics
  • Lalit Kumar Manipal Academy of Higher Education, Manipal College of Pharmaceutical Sciences, Department of Pharmaceutics

DOI:

https://doi.org/10.1590/s2175-97902019000318069

Keywords:

Fluconazole, NLCs, Nanostructured lipid carriers, Fungal infections, Full factorial design, Design of experiment

Abstract

Present study was aimed to prepare and characterize fluconazole loaded nanostructured lipid carriers (FLZ-NLCs) for the treatment of fungal infections. Fungal infections are tremendously widespread and are the often faced dermatological condition worldwide. FLZ-NLCs was prepared by ultrasonication emulsion technique using stearic acid (SA) as solid lipid, castor oil as liquid lipid and tween 20 as a surfactant. The mean diameter of optimized FLZ-NLCs were found to be 359.15 ± 9.83 nm. The drug content and entrapment efficiency of NLCs was found to be 102.97 ± 7.45% and 87 ± 0.59%, respectively. In vitro drug release studies of FLZ-NLCs showed 37.34 ± 2.08% drug release over a period of 72 h. The above studies confirmed the prepared FLZ-NLCs may be useful for the treatment of fungal infections.

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Published

2020-12-09

Issue

Vol. 56 (2020)

Section

Article

License

Copyright (c) 2020 Brazilian Journal of Pharmaceutical Sciences

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How to Cite

Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriers. (2020). Brazilian Journal of Pharmaceutical Sciences, 56, e18069. https://doi.org/10.1590/s2175-97902019000318069