Effect of preparation methods on tosufloxacin tosylate/ hydroxypropyl-β-cyclodextrin inclusion complex

Jianfei Sun; Hailong Hong; Ning Zhu; Limin Han; Quanling Suo

doi:10.1590/s2175-97902022e18650

Authors

Jianfei Sun College of Chemical Engineering, Inner Mongolia University of Technology, Hohhot 010051, China; Inner Mongolia Engineering Research Center for CO2 Capture and Utilization, Hohhot 010051, China https://orcid.org/0000-0001-8126-4988
Hailong Hong College of Chemical Engineering, Inner Mongolia University of Technology, Hohhot 010051, China; Inner Mongolia Engineering Research Center for CO2 Capture and Utilization, Hohhot 010051, China https://orcid.org/0000-0002-7533-4115
Ning Zhu College of Chemical Engineering, Inner Mongolia University of Technology, Hohhot 010051, China; Inner Mongolia Engineering Research Center for CO2 Capture and Utilization, Hohhot 010051, China
Limin Han College of Chemical Engineering, Inner Mongolia University of Technology, Hohhot 010051, China
Quanling Suo College of Chemical Engineering, Inner Mongolia University of Technology, Hohhot 010051, China

DOI:

https://doi.org/10.1590/s2175-97902022e18650

Keywords:

Tosufloxacin tosylate, Hydroxypropyl-β-cyclodextrin, Methods, Inclusion complex

Abstract

The main purpose of this work was to compare the effects of the four preparation methods on the TFLX/HP-β-CD inclusion complex. The effects of different preparation methods on the inclusion complex were investigated by SEM, DSC, PXRD, FT-IR and ¹H NMR. All the characterization information indicated that the four preparation methods could cause interaction between TFLX and HP-β-CD, but the inclusion complex prepared by solvent evaporation has more reaction sites. Phase solubility experiments demonstrated that the inclusion reaction was spontaneous. In vitro dissolution experiments showed that the dissolution of the inclusion complex in water was: solvent evaporation method (64.39%) > grinding method (42.37%) > ultrasonic method (40.00%) > freezing method (36.08%), and all higher than pure TFLX and physical mixture. These results suggest that the solvent evaporation is the most suitable method for preparing TFLX/HP-β-CD inclusion complexes.

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Effect of preparation methods on tosufloxacin tosylate/ hydroxypropyl-β-cyclodextrin inclusion complex

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