Cell phenotypes as activity biomarkers in patients with Systemic Lupus Erythematosus

Authors

  • Cristina de Mello Gomide Loures Universidade Federal de Minas Gerais. Faculdade de Farmácia, Belo Horizonte, Minas Gerais, Brazil
  • Tânia Mara Pinto Dabés Guimarães Universidade Federal de Minas Gerais. Faculdade de Farmácia, Belo Horizonte, Minas Gerais, Brazil
  • Karine Silveste Ferreira Universidade Federal de Minas Gerais. Faculdade de Farmácia, Belo Horizonte, Minas Gerais, Brazil
  • Marcos Vinicius Ferreira Silva Universidade Federal de Minas Gerais. Faculdade de Farmácia, Belo Horizonte, Minas Gerais, Brazil
  • Luan Carlos Vieira Alves Universidade Federal de Minas Gerais. Faculdade de Farmácia, Belo Horizonte, Minas Gerais, Brazil https://orcid.org/0000-0002-9024-8872
  • Fernanda Freire Campos Nunes Universidade Federal de Minas Gerais. Faculdade de Farmácia, Belo Horizonte, Minas Gerais, Brazil
  • Renato Vargas Consoli Santa Casa, Belo Horizonte, Minas Gerais, Brazil
  • Cláudia Lopes Santoro Neiva Santa Casa, Belo Horizonte, Minas Gerais, Brazil
  • Paulo Madureira de Pádua Santa Casa, Belo Horizonte, Minas Gerais, Brazil
  • Luara Isabela dos Santos Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil
  • Josimar Dornelas Moreira Universidade Federal de Minas Gerais. Faculdade de Farmácia, Belo Horizonte, Minas Gerais, Brazil
  • Vicente de Paulo Coelho Peixoto de Toledo Universidade Federal de Minas Gerais. Faculdade de Farmácia, Belo Horizonte, Minas Gerais, Brazil
  • Maria das Graças Carvalho Universidade Federal de Minas Gerais. Faculdade de Farmácia, Belo Horizonte, Minas Gerais, Brazil https://orcid.org/0000-0002-1669-3302

DOI:

https://doi.org/10.1590/s2175-97902023e20052

Keywords:

Systemic Lupus Erythematosus, Lupus nephritis, T cells, B cells, NK cells

Abstract

The pathogenesis of systemic lupus erythematosus (SLE) is complex. Few studies in Brazilian population have addressed cell phenotypes associated with immunological responses and their associations with SLE activity. The aim of this study is to investigate cell phenotypes associated to SLE diagnosis, treatment and activity. Twenty-eight SLE female patients (17 inactive, 11 active) and 10 healthy women were included in this study. Markers of natural killer (Nk), T and B cells in peripheral blood were evaluated by flow cytometry. Nkt cells were decreased only in SLE active patients. Activated CD4+, regulatory T FoxP3+ and B cells were decreased in both active and inactive SLE patients, compared to control group. The data corroborate the disruption of immune regulatory response in SLE patients and suggest phenotipic changes as possible biomarkers of SLE activity.

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References

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Published

2023-04-28

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Original Article

How to Cite

Cell phenotypes as activity biomarkers in patients with Systemic Lupus Erythematosus. (2023). Brazilian Journal of Pharmaceutical Sciences, 59, e20052. https://doi.org/10.1590/s2175-97902023e20052