Formation of hydrophilic fibers containing polyhexamethylene biguanide and hyaluronic acid by electrospinning to wound healing

Authors

  • Lonetá Lauro Lima 3D Technologies Research Group (NT3D), Renato Archer Information Technology Center (CTI), Campinas, SP, Brazil https://orcid.org/0000-0002-2214-7148
  • Roberta Balansin Rigon Center of Cosmetic and Dermatology Specialties (CECD), Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil
  • Marcos Akira d’Ávila School of Mechanical Engineering, University of Campinas (UNICAMP), Campinas, SP, Brazil
  • Pedro Gonçalves de Oliveira Instituto de Ortopedia e Traumatologia, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil; Sports Traumatology Group, Department of Orthopaedics and Traumatology, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil
  • Rodrigo Alvarenga Rezende 3D Technologies Research Group (NT3D), Renato Archer Information Technology Center (CTI), Campinas, SP, Brazil; Postgraduate Program in Biotechnology, Uniara, Araraquara, SP, Brazil
  • Gislaine Ricci Leonardi Center of Cosmetic and Dermatology Specialties (CECD), Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil

DOI:

https://doi.org/10.1590/

Keywords:

Electrospinning, Biomaterial, Chemical stability, PHMB, Hyaluronic acid, Wound dressing

Abstract

For good wound management, simultaneous phases during the wound healing process must be considered, including protection against infection, modulation of the inflammatory process, and proliferation and acceleration of cell migration. The aim of this study was to obtain Poly (Vinyl Pyrrolidone) (PVP) hydrophilic fibers containing polyhexamethylene biguanide (PHMB) and hyaluronic acid (HA) using the electrospinning technique to improve chronic wound treatment. Polymers mean hydrodynamic radius and polydispersity index (PdI) were measured by dynamic light scattering (DLS), whereas fiber morphology and diameter were evaluated by scanning electron microscopy (SEM). Also, Fourier transform infrared spectroscopy (FTIR) and contact angle measurements were performed. Fibers were obtained and presented homogenous morphology with a smooth surface. The FTIR study demonstrated an interaction between C=O groups of PVP and HA/PHMB in the PVP + HA/PHMB fibrous composites. Contact angle analysis has shown a hydrophilic characteristic of fibers produced. These findings demonstrate the great potential of electrospinning for developing drug-delivery systems with antimicrobial properties for wound healing treatment.

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Published

2024-11-05

Issue

Vol. 60 (2024)

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Formation of hydrophilic fibers containing polyhexamethylene biguanide and hyaluronic acid by electrospinning to wound healing. (2024). Brazilian Journal of Pharmaceutical Sciences, 60. https://doi.org/10.1590/

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