A likely case of Theileriosis in cattle in Colombia. First report
DOI:
https://doi.org/10.11606/issn.1678-4456.bjvras.2024.213510Keywords:
Cattle, Theileria, Anemia, Rhipicephalus (Boophilus) microplus, AcidosisAbstract
Bovine theileriosis is a tick-borne disease caused by protozoa of the genus Theileria and may affect different ruminant species, mainly cattle among domesticated species. The disease occurs mainly in tropical and subtropical regions where climate and environmental conditions favor the development of their vectors. The clinical signs vary according to the infecting species. This study aimed to characterize clinically and present the first report of Theileriosis in Holstein and Simmental cows in Colombia. Two 22 month-old pregnant heifers were referred to the Large Animal Clinic at the National University of Colombia with a history of depression, pigmenturia, and dark feces. The main clinical signs on clinical examination were recumbency, severe dehydration (10-12%), icteric mucous membranes, and weak pulse. The blood cell count revealed severe anemia, hypoproteinemia, and lymphopenia; microscopic alterations in red cells, such as structures compatible with Theileria spp., were observed in lymphocytes and red cells. Increased levels of AST, GGT, urea, chloride, and sodium were observed, and the blood gases revealed metabolic acidosis; ventricular tachycardia was observed in one heifer. The anemia and the morphological alterations could be due to the Theileria in the erythrocytes, which increases their elimination rate along with oxidative changes or immune-mediated mechanisms. The observed lymphopenia could be attributed to the microorganisms within the cells that favor cell destruction. An increase in the hepatic enzyme levels might have resulted from anemia and dehydration that causes poor blood perfusion of the liver. The observed metabolic acidosis and hyperlactatemia were associated with inadequate tissue perfusion. In conclusion, this is a likely outbreak of Theileriosis in Holstein and Simmental heifers in Colombia.
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Abdela N, Bekele T. Bovine theileriosis and its control: a review. Adv Biol Res (Faisalabad) [Internet]. 2016a [cited 2023 Mar 2];10(4):200-12. Available from: https://www.idosi.org/abr/10(4)16/1.pdf.
Abdela N, Bekele T. Epidemiology and control of bovine theileriosis in Ethiopia: review. J Med Physiol Biophys [Internet] 2016b [cited 2023 Mar 2];23:32-44. Available from: https://core.ac.uk/download/pdf/234697517.pdf.
Acevedo-Gutiérrez LY, Paternina LE, Pérez-Pérez JC, Londoño AF, López G, Rodas JD. Garrapatas duras (Acari: Ixodidae) de Colombia, una revisión a su conocimiento en el país. Acta Biol Colomb. 2020;25(1):126-39. http://doi.org/10.15446/abc.v25n1.75252.
Agina OA, Shaari MR, Isa NM, Ajat M, Zamri-Saad M, Hamzah H. Clinical pathology, immunopathology and advanced vaccine technology in bovine theileriosis: a review. Pathogens. 2020;9(9):697. http://doi.org/10.3390/pathogens9090697. PMid:32854179.
Ananda KJ, D’Souza PE, Puttalakshmamma GC. Prevalence of Haemoprotozoan diseases in crossbred cattle in Bangalore north. Vet World. 2009;2(1):15-6. http://doi.org/10.5455/vetworld.2009.15-16.
Ayadi O, Gharbi M, Benchikh-Elfegoun MC. Haematological and biochemical indicators of tropical theileriosis diseased cattle in wilaya of Sétif (North East Algeria). J Parasit Dis. 2017;41(2):538-42. http://doi.org/10.1007/s12639-016-0846-6. PMid:28615875.
Aziz K, Qader N, Ibrahim K. Prevalence and hematobiochemical studies on theileriosis in naturally infected cattle in erbil province. Adv Anim Vet Sci. 2022;10(1):49- 54. http://doi.org/10.17582/journal.aavs/2022/10.1.49.54.
Bishop R, Musoke A, Morzaria S, Gardner M, Nene V. Theileria: intracellular protozoan parasites of wild and domestic ruminants transmitted by ixodid ticks. Parasitology. 2004;129(Suppl):S271-83. http://doi.org/10.1017/S0031182003004748. PMid:15938515.
Castañeda-Salazar R, Moreno C, Oliver O, Donado P. Acid-base balance in bovine anaplasmosis. In: Proceedings of the 22nd World Buiatrics Congress; 2002 Aug 18-23; Hannover, Germany. Hannover: World Association for Buiatrics; 2002. p. 23-4.
Charaya G, Goel P, Kaur J, Punia S, Bangar Y, Singh Y. Haematobiochemical alterations in crossbred cattle suffering from theileriosis. Indian J Vet Med [Internet]. 2021 [cited 2023 Mar 2];41(2):22-6. Available from: https://isvm.org.in/backend/web/uploads/Paper4d.pdf.
Cöl R, Uslu U. Changes in selected serum components in cattle naturally infected with Theileria annulata. Bull Vet Inst Pulawy. 2007;51:15-8.
Cöl R, Uslu U. Haematological and coagulation profiles during severe tropical theileriosis in cattle. Turk J Vet Anim Sci [Internet]. 2006 [cited 2023 Mar 2];30(6):577-82. Available from: https://journals.tubitak.gov.tr/veterinary/vol30/iss6/11.
Cortés-Vecino JA, Betancourt-Echeverri JA, ArguellesCárdenas J, Pulido-Herrera LA. Distribución de garrapatas Rhipicephalus (Boophilus) microplus en bovinos y fincas del Altiplano cundiboyacense (Colombia). Cienc Tecnol Agropecu. 2010;11(1):73-84. http://doi.org/10.21930/rcta.vol11_num1_art:197.
Dandasena D, Bhandari V, Sreenivasamurthy GS, Murthy S, Roy S, Bhanot V, Arora JS, Singh S, Sharma P. A Real-Time PCR based assay for determining parasite to host ratio and parasitaemia in the clinical samples of bovine theileriosis. Sci Rep. 2018;8(1):15441. http://doi.org/10.1038/s41598-018-33721-3. PMid:30337565.
El-Dakhly KM, Arafa W, Ghanem SS, Abdel-Fatah OR, Wahba AA. Microscopic and molecular detection of Theileria annulata infection of cattle in Egypt. J Adv Parasitol. 2018;5(2):29-34. http://doi.org/10.17582/journal.jap/2018/5.2.29.34.
El-Deeb WM, Iacob OC. Serum acute phase proteins in control and Theileria annulata infected water buffaloes (Bubalus bubalis). Vet Parasitol. 2012;190(1-2):12-8. http://doi.org/10.1016/j.vetpar.2012.06.019. PMid:22785130.
El-Deeb WM, Younis EE. Clinical and biochemical studies on Theileria annulata in Egyptian buffaloes (Bubalus bubalis) with particular orientation to oxidative stress and ketosis relationship. Vet Parasitol. 2009;164(2-4):301-5. http://doi.org/10.1016/j.vetpar.2009.06.002. PMid:19559534.
Fartashvand M, Nadalian MG, Sakha M, Safi S. Elevated serum cardiac troponin I in cattle with theileriosis. J Vet Intern Med. 2013;27(1):194-9. http://doi.org/10.1111/jvim.12014. PMid:23186228.
Ganaie ZA, Shahardar RA, Maqbool I, Bulbul KH, Allaie KH, Wani ZA. An overview of bovine theileriosis. Int J Vet Sci Anim Husb. 2019;4(1):9-13.
Ganguly A, Bhanot V, Bisla RS, Ganguly I, Singh H, Chaudhri SS. Haematobiochemical alterations and direct blood polymerase chain reaction detection of Theileria annulata in naturally infected crossbred cows. Vet World. 2015;8(1):24-8. http://doi.org/10.14202/vetworld.2015.24-28. PMid:27046990.
Garzón-Audor A, Oliver-Espinosa O, Castañeda-Salazar R. Acid base disorders in hospitalized cattle. Braz J Vet Res Anim Sci. 2020;57(1):e159837. http://doi.org/10.11606/issn.1678-4456.bjvras.2020.159837.
Gul N, Ayaz S, Gul I, Adnan M, Shams S, Akbarl NU. Tropical theileriosis and east coast fever in cattle: present, past and future perspective. Int J Curr Microbiol Appl Sci [Internet]. 2015 [cited 2023 Mar 2];4(8):1000-18. Available from: https://www.ijcmas.com/vol-4-8/Naila%20Gul,%20et%20al.pdf.
Gupta KK, Srivastava M, Sudan V, Singh K, Choudhury S, Shanker D. Variation in cardiac markers and electrocardiographic alterations in young calves naturally infected with bovine tropical theileriosis. Trop Anim Health Prod. 2018;50(6):1227-30. http://doi.org/10.1007/s11250-018-1548-0. PMid:29455427.
Hagiwara K, Tsuji M, Ishihara C, Tajima M, Kurosawa T, Takahashi K. Serum from Theileria sergenti-infected cattle accelerates the clearance of bovine erythrocytes in SCID mice. Parasitol Res. 1995;81(6):470-4. http://doi.org/10.1007/BF00931788. PMid:7567904.
Hansapour A, Moghaddam GA, Nematollahi A. Biochemical, hematological, and electrocardiographic changes in buffaloes naturally infected with Theileria annulata. Korean J Parasitol. 2008;46(4):223-7. http://doi.org/10.3347/kjp.2008.46.4.223. PMid:19127327.
Islam MK, Jabbar A, Campbell BEBE, Cantacessi C, Gasser RB. Bovine theileriosis--an emerging problem in southeastern Australia? Infect Genet Evol. 2011;11(8):2095-7. http://doi.org/10.1016/j.meegid.2011.08.012. PMid:21906697.
Islam ST, Dar RF, Sheikh AA, Dogra P, Gupta R, Patel P, Ganaie MY, Wani JM. Theileriosis in a calf: a case study. Int J Curr Microbiol Appl Sci. 2017;6(10):1400-4. http://doi.org/10.20546/ijcmas.2017.610.165.
Izzo M, Poe I, Horadagoda N, De Vos AJ, House JK. Haemolytic anaemia in cattle in NSW associated with Theileria infections. Aust Vet J. 2010;88(1-2):45-51. http://doi.org/10.1111/j.1751-0813.2009.00540.x. PMid:20148827.
Khan A, Ashfaq K, Din IU, Haq RU, Jamil M, Ullah B, Ullah S, Rehmanh HU, Ullah F. Bovine theileriosis: prevalence, estimation of hematological profile and chemotherapy in Cattle in Dera Ismail Khan, Khyber Pakhtunkhwa Province, Pakistan. ASRJETS. 2017;32(1):8-17.
Khan IA, Khan A, Hussain A, Riaz A, Aziz A. Hematobiochemical alterations in cross bred cattle affected with bovine theileriosis in semi-arid zone. Pak Vet J. 2011;31(2):137-40.
Kim S, Yu D, Kang SW, Chae JB, Choi KS, Kim HC, Park BK, Chae JS, Park J. Hematological changes associated with Theileria orientalis infection in Korean Indigenous cattle. Korean J Parasitol. 2017;55(5):481-9. http://doi.org/10.3347/kjp.2017.55.5.481. PMid:29103263.
Ma Q, Liu J, Li Z, Xiang Q, Wang J, Liu A, Li Y, Yin H, Guan G, Luo J. Clinical and pathological studies on cattle experimentally infected with Theileria annulata in China. Pathogens. 2020;9(9):727. http://doi.org/10.3390/pathogens9090727.
McFadden AMJ, Rawdon TG, Meyer J, Makin J, Morley CM, Clough RR, Tham K, Müllner P, Geysen D. An outbreak of haemolytic anaemia associated with infection of Theileria orientalis in naïve cattle. N Z Vet J. 2011;59(2):79-85. http://doi.org/10.1080/00480169.2011.552857. PMid:21409734.
Mehmet T, Nuri A, Nazmi Y. Relationship between degree of anemia and blood gases in cattle with theileriosis. Turk J Vet Anim Sci. 2014;38(1):82-7. http://doi.org/10.3906/vet-1305-75.
Oliver-Espinosa O, Castañeda-Salazar R. Clinical characterization of hemoparasitism by Babesia spp. and Anaplasma spp. in Wagyu cattle. In: Proceedings of the 31st World Buiatrics Congress; 2022 Sept 4- 8; Madrid, Spain: World Association for Buiatrics; 2022. p. 143.
Omer OH, El-Malik KH, Magzoub M, Mahmoud OM, Haroun EM, Hawas A, Omar HM. Haematological profiles in pure bred cattle naturally infected with Theileria annulata in Saudi Arabia. Vet Parasitol. 2002;107(1-2):161-8. http://doi.org/10.1016/S0304-4017(02)00094-8. PMid:12072222.
Omer OH, El-Malik KH, Magzoub M, Mahmoud OM, Haroun EM, Hawas A, Omar HM. Biochemical profiles in fresian cattle naturally infected with Theileria annulata in Saudi Arabia. Vet Res Commun. 2003;27(1):15-25. http://doi.org/10.1023/A:1022054522725. PMid:12625400.
Osman SA, Al-Gaabary MH. Clinical, haematological and therapeutic studies on tropical theileriosis in water buffaloes (Bubalus bubalis) in Egypt. Vet Parasitol. 2007;146(3- 4):337-40. http://doi.org/10.1016/j.vetpar.2007.03.012. PMid:17420101.
Patial V, Gupta T, Angaria S, Bali D, Katoch A, Gautam M, Singh NK, Sharma M, Chahota R. Theileria orientalis outbreak in an organized cattle breeding farm. Vet Parasitol Reg Stud Rep. 2021;24:100572. http://doi.org/10.1016/j.vprsr.2021.100572. PMid:34024388.
Perera P, Gasser R, Anderson G, Jeffers M, Bell C, Jabbar A. Epidemiological survey following oriental theileriosis outbreaks in Victoria, Australia, on selected cattle farms. Vet Parasitol. 2013;197(3-4):509-21. http://doi.org/10.1016/j.vetpar.2013.06.023. PMid:23896063.
Perera PK, Gasser RB, Firestone SM, Anderson GA, Malmo J, Davis G, Beggs DS, Jabbar A. Oriental theileriosis in dairy cows causes a significant milk production loss. Parasit Vectors. 2014;7(1):73-80. http://doi.org/10.1186/1756-3305-7-73. PMid:24552213.
Radostits OM, Gay CC, Hinchcliff KW, Constable PD. Theilerioses. In: Radostits OM, Gay CC, Hinchcliff KW, Constable PD, editors. Veterinary medicine. 10th ed. Spain: Saunders Elsevier; 2007. p. 1526-31.
Ruggiero MA, Gordon DP, Orrell TM, Bailly N, Bourgoin T, Brusca RC, Cavallier-Smith T, Guiry MD, Kirk PM. Correction: a higher-level classification of all living organisms. PLoS One. 2015;10(6):e0130114. http://doi.org/10.1371/journal.pone.0130114. PMid:26068874.
Saber APR, Khorrami M, Nouri M. Evaluation of haematochemical parameters in crossbred cattle naturally infected with Theileria annulata in Iran. Int J Dairy Sci. 2008;3(4):205-9. http://doi.org/10.3923/ijds.2008.205.209.
Selim A, Weir W, Khater H. Prevalence and risk factors associated with tropical theileriosis in Egyptian dairy cattle. Vet World. 2022;15(4):919-24. http://doi.org/10.14202/vetworld.2022.919-924. PMid:35698515.
Sharkey L, Burton E. Alterations in the erythron. In: Bradford PS, van Metre DC, Pusterla N, editors. Large animal internal medicine. 6th ed. USA: Elsevier; 2019. p. 424-8.
Sharkey L, Heinrich D. Alteration in the leukogram. In: Bradford PS, van Metre DC, Pusterla N, editors. Large animal internal medicine. 6th ed. USA: Elsevier; 2019. p. 429-34.
Sherlock M, Healy AM, Doherty ML. Acid-base balance in field cases of bovine babesiosis. Vet Rec. 2003;152(22):687- 8. http://doi.org/10.1136/vr.152.22.687. PMid:12803396.
Shimizu S, Yagi Y, Nakamura Y, Shimura K, Fujisaki K, Onodera T, Minami T, Ito S. Clinico-hematological observation of calves experimentally infected with Theileria sergenti. Nippon Juigaku Zasshi. 1990;52(6):1337-9. http://doi.org/10.1292/jvms1939.52.1337. PMid:2287144.
Singh A, Singh J, Grewal AS, Brar RS. Studies on some blood parameters of crossbred calves with experimental Theileria annulata infections. Vet Res Commun. 2001;25(4):289-300. http://doi.org/10.1023/A:1010678625336. PMid:11432430.
Sitotaw T, Regassa F, Zeru F, Kahsay A. Epidemiological significance of major hemoparasites of ruminants in and around Debre-Zeit, Central Ethiopia. J Parasitol Vector Biol [Internet]. 2014 [cited 2023 Mar 2];6(2):16- 22. Available from: https://academicjournals.org/article/article1392277484_Sitotaw%20et%20al.pdf.
Somu Y, Mani S, Muthusamy R, Mani S, Thangamani A, Konappan J, Muthusamy V, Subbaih KK, Palanisamy S. Haemato- biochemical and electrolyte alterations in naturally occurring Theileria associated bovine anaemia (Taba). J Anim Health Prod [Internet]. 2017 [cited 2023 Mar 2];5(2):64-7. Available from: https://researcherslinks.com/nexus_uploads/files/JAHP_5_2_64-67.pdf.
Spickler AR. Theileriosis in cattle and small ruminants [Internet]. USA: USDA; 2019 [cited 2023 Mar 2]. Available from: https://www.cfsph.iastate.edu/Factsheets/pdfs/theileriosis_theileria_parva_and_theileria_annulata.pdf.
Staempfli H, Oliver-Espinosa O. Clinical chemistry tests. In: Bradford PS, van Metre DC, Pusterla N, editors. Large animal internal medicine. 6th ed. USA: Elsevier; 2019. p. 395-420.
Stockham SL, Kjemtrup AM, Conrad PA, Schmidt DA, Scott MA, Robinson TW, Tyler JW, Johnson GC, Carson CA, Cuddihee P. Theileriosis in a Missouri beef herd caused by Theileria buffeli: case report, herd investigation, ultrastructure, phylogenetic analysis, and experimental transmission. Vet Pathol. 2000;37(1):11-21. http://doi.org/10.1354/vp.37-1-11. PMid:10643976.
Temiz M, Altuğ N, Yüksek N. Relationship between degree of anemia and blood gases in cattle with theileriosis. Turk J Vet Anim Sci. 2014;38:82-7. http://doi.org/10.3906/vet1305-75.
Watts JG, Playford MC, Hickey KL. Theileria orientalis: a review. N Z Vet J. 2016;64(1):3-9. http://doi.org/10.1080/00480169.2015.1064792. PMid:26143684.
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