Associação entre a intensidade do eco do quadríceps femoral, desfechos reportados pelos pacientes e capacidade funcional em pessoas com fibromialgia
DOI:
https://doi.org/10.11606/issn.2317-0190.v33e241431Palavras-chave:
Dor, Estado Funcional, Doenças Reumáticas, UltrassonografiaResumo
Objetivo: Investigar a associação entre a intensidade do eco do quadríceps (qualidade muscular), os desfechos reportados pelos pacientes e a capacidade funcional em pessoas com fibromialgia. Método: Imagens do quadríceps foram geradas usando ultrassom e a intensidade do eco foi medida com o software Image-J. Os desfechos incluíram dor em repouso e durante o movimento, catastrofização da dor e fadiga. A capacidade funcional foi medida com o Teste de Sentar e Levantar Cinco Vezes, o Timed Up and Go (habitual e rápido) e o Teste de Subir Escadas. As correlações entre variáveis foram analisadas com o coeficiente de Spearman. Resultados: Quarenta e quatro pessoas com fibromialgia, média de 48,2 ± 8,9 anos, foram incluídas. Não foram encontradas associações significativas entre a intensidade do eco do quadríceps e os desfechos reportados ou a capacidade funcional. No entanto, os desfechos reportados apresentaram associação significativa com a capacidade funcional, destacando-se associação positiva entre o Timed Up and Go rápido, dor em repouso (r= 0,563, IC 95%: 0,279 a 0,732; p < 0,001),) e fadiga (r= 0,512, IC 95%: 0,281 a 0,705; p < 0,001). Conclusão: Em pessoas com fibromialgia, maiores níveis de dor e fadiga estão associados a pior desempenho no teste de caminhada rápida, enquanto a qualidade muscular do quadríceps não se correlaciona com desfechos autorrelatados ou capacidade funcional.
Downloads
Referências
Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Häuser W, Katz RL, et al. 2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum. 2016;46(3):319-329. Doi: https://doi.org/10.1016/j.semarthrit.2016.08.012
Vecchio E, Lombardi R, Paolini M, Libro G, Delussi M, Ricci K, et al. Peripheral and central nervous system correlates in fibromyalgia. Eur J Pain. 2020;24(8):1537-1547. Doi: https://doi.org/10.1002/ejp.1607
Ruggiero L, Manganelli F, Santoro L. Muscle pain syndromes and fibromyalgia: the role of muscle biopsy. Curr Opin Sup- port Palliat Care. 2018;12(3):382-387. Doi: https://doi.org/10.1097/SPC.0000000000000355
Gerdle B, Dahlqvist Leinhard O, Lund E, Bengtsson A, Lundberg P, Ghafouri B, et al. Fibromyalgia: Associations Between Fat Infiltration, Physical Capacity, and Clinical Variables. J Pain Res. 2022;15:2517-2535. Doi: https://doi.org/10.2147/JPR.S376590
Balaban M, Toprak Celenay S, Lalecan N, Akan S, Ozer Kaya D. Morphological and mechanical properties of cervical muscles in fibromyalgia with migraine: A case-control study. Musculoskelet Sci Pract. 2024;74:103185. Doi: https://doi.org/10.1016/j.msksp.2024.103185
Mesci E, Dogruoz B, Mesci N, Icagasioglu A. Ultrasonographic evaluation of muscle thickness in female patients with fibromyalgia and its relationship with clinical para meters. North Clin Istanb. 2023;10(6):718-725. Doi: https://doi.org/10.14744/nci.2023.04382
Kuzu Ö, Aras B. Sonographic measurement of the neck extensor muscle thickness in patients with fibromyalgia. Musculoskelet Sci Pract. 2022;59:102541. Doi: https://doi.org/10.1016/j.msksp.2022.102541
Umay E, Gundogdu I, Ozturk EA. What happens to muscles in fibromyalgia syndrome. Ir J Med Sci. 2020;189(2):749-756. Doi: https://doi.org/10.1007/s11845-019-02138-w
Thomas DM, Crofford I, Scudder J, Oletti B, Deb A, Heymsfield SB. Updates on Methods for Body Composition Analysis: Implications for Clinical Practice. Curr Obes Rep. 2025;14(1):8. Doi: https://doi.org/10.1007/s13679-024-00593-w
Taniguchi M, Fukumoto Y, Yagi M, Motomura Y, Okada S, Okada S, et al. Enhanced echo intensity in vastus medialis is associated with worsening of functional disabilities and symptoms in patients with knee osteoarthritis: a 3 years longitudinal study. Rheumatol Int. 2023;43(5):953-960. Doi: https://doi.org/10.1007/s00296-022-05246-6
Stock MS, Thompson BJ. Echo intensity as an indicator of skeletal muscle quality: applications, methodology, and future directions. Eur J Appl Physiol. 2021;121(2):369-380. Doi: https://doi.org/10.1007/s00421-020-04556-6
Tavares LF, Germano Maciel D, Silva TYPB, Vieira WHB. Comparison of functional and isokinetic performance between healthy women and women with fibromyalgia. J Bodyw Mov Ther. 2020;24(1):248-252. Doi: https://doi.org/10.1016/j.jbmt.2019.05.024
Soriano-Maldonado A, Henriksen M, Segura-Jiménez V, Aparicio VA, Carbonell-Baeza A, Delgado-Fernández M, et al. Association of Physical Fitness With Fibromyalgia Severity in Women: The al-Ándalus Project. Arch Phys Med Rehabil. 2015;96(9):1599-605. Doi: https://doi.org/10.1016/j.apmr.2015.03.015
Souza JB, Perissinotti DMN. The prevalence of fibromyalgia in Brazil – a population-based study with secondary data of the study on chronic pain prevalence in Brazil. BrJP. 2018;1(4):345-8. Doi: https://doi.org/10.5935/2595-0118.20180065
Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Katz RS, Mease P, et al. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken). 2010;62(5):600-10. Doi: https://doi.org/10.1002/acr.20140
Marques AP, Santos AMB, Assumpção A, Matsutani LA, Lage LV, Pereira CAB. Validação da versão brasileira do Fibromyalgia Impact Questionnaire (FIQ). Rev Bras Reumatol. 2006;46(1):24-31. Doi: https://doi.org/10.1590/S0482-50042006000100006
Farrar JT, Young JP Jr, LaMoreaux L, Werth JL, Poole MR. Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain. 2001;94(2):149-158. Doi: https://doi.org/10.1016/S0304-3959(01)00349-9
Sullivan MJL, Bishop SR, Pivik J. The Pain Catastrophizing Scale: Development and validation. Psychological Assessment. 1995;7(4):524-532. Doi: https://doi.org/10.1037/1040-3590.7.4.524
Valderramas S, Feres AC, Melo A. Reliability and validity study of a Brazilian-Portuguese version of the fatigue severity scale in Parkinson's disease patients. Arq Neuropsiquiatr. 2012;70(7):497-500. Doi: https://doi.org/10.1590/s0004-282x2012000700005
Taniguchi M, Fukumoto Y, Kobayashi M, Kawasaki T, Maegawa S, Ibuki S, et al. Quantity and Quality of the Lower Extremity Muscles in Women with Knee Osteoarthritis. Ultrasound Med Biol. 2015;41(10):2567-74. Doi: https://doi.org/10.1016/j.ultrasmedbio.2015.05.014
Oranchuk DJ, Stock MS, Nelson AR, Storey AG, Cronin JB. Variability of regional quadriceps echo intensity in active young men with and without subcutaneous fat correction. Appl Physiol Nutr Metab. 2020;45(7):745-752. Doi: https://doi.org/10.1139/apnm-2019-0601
Young HJ, Jenkins NT, Zhao Q, Mccully KK. Measurement of intramuscular fat by muscle echo intensity. Muscle Nerve. 2015;52(6):963-71. Doi: https://doi.org/10.1002/mus.24656
Yoshioka S, Nagano A, Hay DC, Fukashiro S. Biomechanical analysis of the relation between movement time and joint moment development during a sit-to-stand task. Biomed Eng Online. 2009;8:27. Doi: https://doi.org/10.1186/1475-925X-8-27
Dobson F, Hinman RS, Roos EM, Abbott JH, Stratford P, Davis AM, et al. OARSI recommended performance-based tests to assess physical function in people diagnosed with hip or knee osteoarthritis. Osteoarthritis Cartilage. 2013;21(8):1042-52. Doi: https://doi.org/10.1016/j.joca.2013.05.002
Cohen J. Statistical power analysis for the behavioral sciences. 1st ed. New York: Academic Press; 1977.
Abiko T, Ohmae K, Murata S, Shiraiwa K, Horie J. Reliability of muscle thickness and echo intensity measurements of the quadriceps: A novice examiner. J Bodyw Mov Ther. 2022;31:164-168. Doi: https://doi.org/10.1016/j.jbmt.2022.03.004
Jurado-Priego LN, Cueto-Ureña C, Ramírez-Expósito MJ, Martínez-Martos JM. Fibromyalgia: A Review of the Patho- physiological Mechanisms and Multidisciplinary Treatment Strategies. Biomedicines. 2024;12(7):1543. Doi: https://doi.org/10.3390/biomedicines12071543
Casas-Barragán A, Molina F, Tapia-Haro RM, García-Ríos MC, Correa-Rodríguez M, Aguilar-Ferrándiz ME. Association of core body temperature and peripheral blood flow of the hands with pain intensity, pressure pain hypersensitivity, central sensitization, and fibromyalgia symptoms. Ther Adv Chronic Dis. 2021;12:2040622321997253. Doi: 10.1177/2040622321997253
Siracusa R, Paola RD, Cuzzocrea S, Impellizzeri D. Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update. Int J Mol Sci. 2021;22(8):3891. Doi: https://doi.org/10.3390/ijms22083891
Serpas DG, Zettel-Watson L, Cherry BJ. Fibromyalgia status and depressive symptoms are linked to body mass index and physical performance in mid to late life. Psychol Health Med. 2023;28(5):1230-1243. Doi: https://doi.org/10.1080/13548506.2021.2002379
Meral HB, Rezvani A, Tolu S, Usen A, Dasdelen MF. Structural changes in the upper trapezius muscle of fibromyalgia patients identified by quantitative ultrasonography: a cross- sectional study. Rheumatol Int. 2025;45(5):115. Doi: https://doi.org/10.1007/s00296-025-05871-x
Wilk M, Zimba O, Haugeberg G, Korkosz M. Pain catastrophizing in rheumatic diseases: prevalence, origin, and implications. Rheumatol Int. 2024;44(6):985-1002. Doi: https://doi.org/10.1007/s00296-024-05583-8
Apriliyasari RW, Chou CW, Tsai PS. Pain Catastrophizing as a Mediator Between Pain Self-Efficacy and Disease Severity in Patients with Fibromyalgia. Pain Manag Nurs. 2023;24(6):622-626. Doi: https://doi.org/10.1016/j.pmn.2023.05.003
Galvez-Sánchez CM, Montoro CI, Duschek S, Del Paso GAR. Pain catastrophizing mediates the negative influence of pain and trait-anxiety on health-related quality of life in fi- bromyalgia. Qual Life Res. 2020;29(7):1871-1881. Doi: https://doi.org/10.1007/s11136-020-02457-x
Velasco L, López-Gómez I, Gutiérrez L, Écija C, Catalá P, Peñacoba C. Exploring the Preference for Fatigue-avoidance Goals as a Mediator Between Pain Catastrophizing, Functional Impairment, and Walking Behavior in Women With Fibromyalgia. Clin J Pain. 2021;38(3):182-188. Doi: https://doi.org/10.1097/AJP.0000000000001010
Raja SN, Carr DB, Cohen M, Finnerup NB, Flor H, Gibson S, et al. The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain. 2020;161(9):1976-1982. Doi: https://doi.org/10.1097/j.pain.0000000000001939
Kosek E. The concept of nociplastic pain-where to from here? Pain. 2024;165(11S):S50-S57. Doi: https://doi.org/10.1097/j.pain.0000000000003305
Romeo A, Di Tella M, Benfante A, Colonna F, Castelli L. Met- acognition and pain in patients with fibromyalgia: the role of psychological distress. J Affect Disord. 2025;382:85-88. Doi: https://doi.org/10.1016/j.jad.2025.04.062
Baris E, Topaloglu I, Akalin E, Hamurtekin E, Kabaran S, Gelal A, et al. Serum choline, leptin and interleukin-6 levels in fi- bromyalgia syndrome-induced pain: a case-control study. BMC Musculoskelet Disord. 2025;26(1):97. Doi: https://doi.org/10.1186/s12891-025-08337-0
González-Álvarez ME, Riquelme-Aguado V, González-Pérez Á, Murillo-Llergo R, Manjón-Olmedillas M, Turroni S, et al. Association Between Systemic Neuroinflammation, Pain Perception and Clinical Status in Fibromyalgia Patients: Cross-Sectional Study. Cells. 2024;13(20):1719. Doi: https://doi.org/10.3390/cells13201719
Kulshreshtha P, Deepak KK. Personality construct as a biomarker in fibromyalgia: A narrative review from an autonomic rehabilitation perspective. J Back Musculoskelet Rehabil. 2023;36(6):1251-1260. Doi: https://doi.org/10.3233/BMR-220353
Carrasco-Vega E, Ruiz-Muñoz M, Cuesta-Vargas A, Romero-Galisteo RP, González-Sánchez M. Individuals with fibromyalgia have a different gait pattern and a reduced walk functional capacity: a systematic review with meta-analysis. PeerJ. 2022;10:e12908. Doi: https://doi.org/10.7717/peerj.12908
Dailey DL, Frey Law LA, Vance CG, Rakel BA, Merriwether EN, Darghosian L, et al. Perceived function and physical performance are associated with pain and fatigue in women with fibromyalgia. Arthritis Res Ther. 2016;18:68. Doi: https://doi.org/10.1186/s13075-016-0954-9
Downloads
Publicado
Edição
Seção
Licença
Direitos autorais (c) 2026 Acta Fisiátrica

Este trabalho está licenciado sob uma licença Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
O conteúdo do periódico está licenciado sob uma Licença Creative Commons BY-NC-SA. Esta licença permite que outros remixem, adaptem e criem a partir do seu trabalho para fins não comerciais, desde que atribuam ao autor o devido crédito e que licenciem as novas criações sob termos idênticos.








