The potentiating effect of chloramphenicol succinate in rat carrageenininduced acute pleurisy. Inhibition by indomethacin and dexamethasone

Authors

  • Julieta Rodini Engrácia de Moraes Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Departamento de Patologia Veterinária, Jaboticabal, SP
  • Flávio Ruas de Moraes Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Departamento de Patologia Veterinária, Jaboticabal, SP
  • Gervásio Henrique Bechara Universidade Estadual Paulista, Faculdade de Ciências Agrárias e Veterinárias, Departamento de Patologia Veterinária, Jaboticabal, SP

DOI:

https://doi.org/10.11606/issn.2318-3659.v33i1p11-14

Keywords:

Chloramphenicol, Pleurisy, Carrageenin, Dextran, Indomethacin, Dexamethasone.

Abstract

The effect of indomethacin and dexamethasone on PMN cell migration was studied in relation to chloramphenicol in the pleural cavity of rats, 4 hours after local injection of carrageenin or dextran. Pre-treatment of rats with chloramphenicol succinate (30mg/kg), ip, every 12h, during 4 days, potentiated the migration of PMN leucocytes to the inflamed cavity, when carrageenin (150mcg) was used as an irritant. However, responses to dextran (100mcg) remained the same. Chloramphenicol pre-treated rats that received
indomethacin (2mg/kg, per os, 30min before carrageenin) or dexamethasone (0.25mg/kg, ip, 30min before carrageenin) showed inhibition of potentiated cellular responses. Mechanisms of the potentiating effect of chloramphenicol on the acute carrageenin-induced inflammation remains unclear.

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Published

1996-03-01

Issue

Vol. 33 No. 1 (1996)

Section

BASIC SCIENCES

License

The journal content is authorized under the Creative Commons  BY-NC-SA  license (summary of the license: https://creativecommons.org/licenses/by-nc-sa/4.0 | full text of the license: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode) 

How to Cite

1.
Moraes JRE de, Moraes FR de, Bechara GH. The potentiating effect of chloramphenicol succinate in rat carrageenininduced acute pleurisy. Inhibition by indomethacin and dexamethasone. Braz. J. Vet. Res. Anim. Sci. [Internet]. 1996 Mar. 1 [cited 2025 Feb. 16];33(1):11-4. Available from: https://revistas.usp.br/bjvras/article/view/50271