Nonsteroidal anti-inflammatory drugs nephrotoxicity

Authors

  • Sarah Suyanne Carvalho Melgaço Universidade Federal do Ceará
  • Maria Isabel Ramos Saraiva Universidade Federal do Ceará
  • Taís Teixeira Correia Lima Universidade Federal do Ceará
  • Geraldo Bezerra Silva Júnior Departamento de Medicina Clínica, Universidade Federal do Ceará
  • Elizabeth Francesco Daher Departamento de Medicina Clínica, Universidade Federal do Ceará

DOI:

https://doi.org/10.11606/issn.2176-7262.v43i4p382-390

Keywords:

Anti-Inflammatory Agents, Non-Steroidal. Drug Toxicity. Kidney/drug effects. Renal Insufficiency.

Abstract

Nonsteroidal antiinflammatory drugs (NSAIDs) constitute the most commonly prescribed drug all over the world. The frequency of their use has increased in the past years. The association between the use of NSAIDs and renal failure is well established and occurs due to renal compensatory vasodilatation, along with cytokine release, which causes glomerular lesion. Renal damage constitutes one of the main reasons for the high rate of morbimortality associated to the indiscriminated use of NSAIDs. In this article we review the literature about nephrotoxicity of NSAIDs, evaluating the pathophysiology and the main clinical features of different kinds of renal injuries

Downloads

Download data is not yet available.

Author Biographies

  • Sarah Suyanne Carvalho Melgaço, Universidade Federal do Ceará

    Acadêmica de Medicina, Universidade Federal do Ceará

  • Maria Isabel Ramos Saraiva, Universidade Federal do Ceará

    Acadêmica de Medicina, Universidade Federal do Ceará. Fortaleza

  • Taís Teixeira Correia Lima, Universidade Federal do Ceará

    Acadêmica de Medicina, Universidade Federal do Ceará. Fortaleza

  • Geraldo Bezerra Silva Júnior, Departamento de Medicina Clínica, Universidade Federal do Ceará

    Professor Substituto da Disciplina de Nefrologia, Aluno do curso de Mestrado em Ciências Médicas, Departamento de Medicina Clínica, Universidade Federal do Ceará

  • Elizabeth Francesco Daher, Departamento de Medicina Clínica, Universidade Federal do Ceará

    Professora Adjunta da Disciplina de Nefrologia, Departamento de Medicina Clínica, Universidade Federal do Ceará

Downloads

Published

2010-12-30

Issue

Vol. 43 No. 4 (2010)

Section

Review

License

 

 

How to Cite

1.
Melgaço SSC, Saraiva MIR, Lima TTC, Silva Júnior GB, Daher EF. Nonsteroidal anti-inflammatory drugs nephrotoxicity. Medicina (Ribeirão Preto) [Internet]. 2010 Dec. 30 [cited 2024 May 27];43(4):382-90. Available from: https://revistas.usp.br/rmrp/article/view/188